The increase in body temperature (hyperthermia) in most cases caused by the appearance in the blood special substances pyrogen free. They are exogenous and androgennami.
Exogenous pyrogens enter the body from outside and are nothing but microbes and their metabolic products. On their own they do not cause hyperthermia.
In the human body upon detection of exogenous pyrogens activated protective mechanism, resulting in the immune cells start the process of producing their internal (endogenous) pyrogen free, representing interferons, cytokines, interleukins and various breakdown products of steroid hormones.
The signal about the presence in the blood of pyrogen free androginnyh enters the thermoregulation center of the hypothalamus located in the brain. The hypothalamus makes adjustments in the mechanism of thermoregulation, interpreting the current body temperature as lower, and shifts the value in the normal temperature up. The body temperature begins to rise.
The temperature increase is mainly due to the recoil body heat to the external environment. The blood vessels narrow, the amount of blood delivered to the peripheral tissues, is significantly reduced, the processes of sweating are inhibited or stopped completely. The temperature of the skin decreases, the skin turns pale, there is a fever and shivering.
Raising the body temperature to the new value, the hypothalamus sends the body a signal about its maintenance at the set level. To further temperature increase did not occur, the thermoregulatory center balances heat production and heat by expanding blood vessels and increasing blood circulation in the body. Body skin is pink and hot, chills, and the shivers disappear, giving way to the heat.
When following recovery, medication or perform antipyretic measures the number of endogenous pyrogens in the body decreases, or becomes void, the centre of thermoregulation again shifts the value in the normal temperature, but now down. After adjustments have been made the hypothalamus identifies the current temperature as increased and signals the body to lower the temperature by increasing the heat transfer.
Because the most effective way to remove heat from the body is perspiration, the dilation of blood vessels, activation of sweat glands. The sweat evaporates from the skin surface, it absorbs heat and reduces body temperature.
Causes of hyperthermia
Most often fever cause acute respiratory viral infection, pathogens are rhinoviruses, reoviruses, adenoviruses, and influenza viruses, and parainfluenza.
Hyperthermia is almost always accompanies intestinal infections. In this case, the increased temperature adjacent to the typical signs of gastro-intestinal disorders – bloating, diarrhea, nausea, and vomiting.
Much more rarely, but it happens that the body temperature rises due to intolerance or overdose of antidepressants, psychostimulants, anesthetics and salicylates. Causes of hyperthermia can be of poisoning by toxic substances and moved deep emotional and psychological experiences.
In the end, the body temperature can rise due to heat or sunstroke.
to Knock or not to knock?
According to modern medical science, the self heating of the body is his natural defensive reaction designed to neutralize and destroy the source of infection.
With increasing temperature there is a revitalization and acceleration of all metabolic processes in the body, increases production of interferon and antibodies in the liver is an intensive detoxification of toxins and send them through the urinary system with urine and feces.
However, not all hyperthermia is useful. The fact is that due to the activation of all processes in the body significantly increases, the need for tissues and organs of nutrients and oxygen, causing stress on the lungs and heart increases significantly.
Therefore, people suffering from shortness of breath and irregularities in the cardiovascular system, as well as children are encouraged to bring a fever down when she reaches the values 38,00 – 38,50 C. In the case of poor tolerance of high temperature antipyretic activities to be undertaken and at lower temperatures.
Take care of yourself! Be always healthy!